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Cheng, JW; Zong, Y; Zeng, YY; Wei, RL (2014). Archived from the original on 28 November 2010. More compounds in this class are being investigated in phase 2 and phase 3 trials. Loss of aqueous humor absorption leads to increased resistance and thus a chronic, painless buildup of pressure in the eye. Screening edit The United States Preventive Services Task Force stated, as of 2013, that there was insufficient evidence to recommend for or against screening for glaucoma. Primary juvenile glaucoma is a neonate or juvenile abnormality where ocular hypertension is evident at birth or shortly thereafter and is caused by abnormalities in the anterior chamber angle development that blocks the outflow of the aqueous humor. 20 Glaucoma, particularly primary open-angle glaucoma, is associated with mutations in several genes, including myoc, ASB10, WDR36, NTF4, TBK1, 21 and rpgrip1, 22 although most cases of glaucoma do not involve these genetic mutations. Logan's Medical and Scientific Abbreviations. Main article: Glaucoma surgery Both laser and conventional surgeries are performed to treat glaucoma. Medication edit Latanoprost Main article: Glaucoma medication Intraocular pressure can be lowered with medication, usually eye drops.